General
Preferred name
PFI-6
Synonyms
P&D ID
PD132007
CAS
2675452-91-0
Tags
available
probe
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
family-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3).
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
Cayman Chemical Bioactives
Chemical Probes.org
Enamine Bioactive Compounds
EUbOPEN Chemogenomics Library
High-quality chemical probes
SGC Probes
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
6
Molecular Weight
391.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.17
TPSA
95.67
Fraction CSP3
0.23
Chiral centers
1.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target subclass
YEATS
YEATS, YEATS
Target class
Epigenetics
Epigenetic, Epigenetic
Orthogonal probe
SGC-iMLLT
Target
MLLT1
MLLT3
MLLT1, MLLT3
Control
PFI-6N
Recommended Cell Concentration
1 uM
Source data
